Pharmacogenomics: analysing SNPs in the CYP2D6 gene using amino acid properties
by Mark T.W. Ebbert, Wesley A. Beckstead, Timothy D. O'Connor, Mark J. Clement, David A. McClellan
International Journal of Bioinformatics Research and Applications (IJBRA), Vol. 3, No. 4, 2007

Abstract: The CYP2D6 gene is responsible for metabolising a large portion of the commonly prescribed drugs. Because of its importance, various approaches have been taken to analyse CYP2D6 and Single Nucleotide Polymorphisms (SNPs) throughout its sequence. This study introduces a novel method to analyse the effects of SNPs on encoded protein complexes by focusing on the biochemical properties of each non-synonymous substitution using the program TreeSAAP. Our results show four SNPs in CYP2D6 that exhibit radical changes in amino acid properties which may cause a lack of functionality in the CYP2D6 gene and contribute to a person's inability to metabolise specific drugs.

Online publication date: Mon, 15-Oct-2007

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