Title: Investigation of chitosan/poly(vinyl alcohol)/curcumin film for wound dressing application

Authors: Do Trung Nguyen; Bang Tam Dao Thi; Hon Nhien Le; Chi Nhan Ha Thuc

Addresses: Faculty of Materials Science and Technology, University of Science, VNUHCM, 227 Nguyen Van Cu Street, Ward 4, District 5, Ho Chi Minh City, 700000, Vietnam; Vietnam National University, Linh Trung Ward, Thu Duc City, Ho Chi Minh City, 700000, Vietnam ' Faculty of Materials Science and Technology, University of Science, VNUHCM, 227 Nguyen Van Cu Street, Ward 4, District 5, Ho Chi Minh City, 700000, Vietnam; Vietnam National University, Linh Trung Ward, Thu Duc City, Ho Chi Minh City, 700000, Vietnam ' Faculty of Materials Science and Technology, University of Science, VNUHCM, 227 Nguyen Van Cu Street, Ward 4, District 5, Ho Chi Minh City, 700000, Vietnam; Vietnam National University, Linh Trung Ward, Thu Duc City, Ho Chi Minh City, 700000, Vietnam ' Faculty of Materials Science and Technology, University of Science, VNUHCM, 227 Nguyen Van Cu Street, Ward 4, District 5, Ho Chi Minh City, 700000, Vietnam; Vietnam National University, Linh Trung Ward, Thu Duc City, Ho Chi Minh City, 700000, Vietnam

Abstract: This research presents the preparation of polymeric thin films from chitosan (CS) and polyvinyl alcohol (PVA) for application in healing wounds and burns. Synthetically, chitosan solution containing 2% chitosan and 2% acetic acid is mixed with polyvinyl alcohol solution 2%. The casting of CS/PVA mixtures at 60°C produces homogeneous CS/PVA thin films. In addition, to improve the stability of CS/PVA films in aqueous environments, citric acid is added to make CS/PVA films crosslinked and durable, especially when in contact with wounds and secretions in a long time. Particularly, to attain effective antibacterial activity, natural curcumin is extracted from yellow turmerics in order to modify CS/PVA films. Morphology, structure and antimicrobial properties of as-prepared CS/PVA/Cur films are investigated using UV-VIS, FTIR, SEM and mechanical tensile measurement methods. On the basis of analytical results, the blend films are evaluated and improved for potential application of wound dressing.

Keywords: wound dressing; crosslinking; chitosan; polyvinyl alcohol; curcumin.

DOI: 10.1504/IJNT.2024.146456

International Journal of Nanotechnology, 2024 Vol.21 No.7/8/9/10/11/12, pp.524 - 535

Published online: 30 May 2025 *

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