Title: An overview on 3D-bioprinting techniques for developing the biochip DNA sensors

Authors: Majid Monajjemi; Dung My Thi Dang; Chien Mau Dang; Fatemeh Mollaamin

Addresses: Department of Chemical Engineering, Central Tehran Branch, Islamic Azad University, Tehran, 1477893855, Iran; Institute for Nanotechnology, Community 6, Linh Trung Ward, Thu Duc City, Ho Chi Minh City, 700000, Vietnam ' Institute for Nanotechnology, Community 6, Linh Trung Ward, Thu Duc City, Ho Chi Minh City, 700000, Vietnam; Vietnam National University Ho Chi Minh City, Community 6, Linh Trung Ward, Thu Duc City, Ho Chi Minh City, 700000, Vietnam ' Institute for Nanotechnology, Community 6, Linh Trung Ward, Thu Duc City, Ho Chi Minh City, 700000, Vietnam; Vietnam National University Ho Chi Minh City, Community 6, Linh Trung Ward, Thu Duc City, Ho Chi Minh City, 700000, Vietnam ' Faculty of Engineering and Architecture, Department of Biomedical Engineering, Kastamonu University, Kastamonu, 37150, Turkey

Abstract: One of the biggest targets of using biochips in human tissues is their effective and efficient screening of biological analyses with high applications from cancer diagnosis to detection of bio-disease roots. In past decades, the activity for the tissue-chip (TC) model has gained great attention from scientists worldwide. Powerful instruments for biomedical engineering research, including disease modelling, drug designing, and nano-drug delivery, have been investigated extensively by researchers. This review highlights the important points and background of biochip development. Herein, we concentrate on applications of lab chips (LCs) instruments as a versatile tool for point of healthcare (PHC) applications. We also review current progress in various platforms towards biochip DNA sensors as an alternative to the general bio-electrochemical sensors. The fundamentals of optical sensing are generally based on the intercalation between glass surfaces consisting of DNA and any kind of light, such as absorption, fluorescence or reflectance light, which depends on the optical characteristics of the chemical agents of the matrix used. Recently, the situation of novel techniques employing optical fibre has progressed significantly, and we suggest highlighted remarks and future perspectives on these kinds of platforms for PHC applications.

Keywords: microfluidics; biochips; system-on-chip; PHC; point of healthcare; lab chips; DNA sensors; ink-jet.

DOI: 10.1504/IJNT.2024.146454

International Journal of Nanotechnology, 2024 Vol.21 No.7/8/9/10/11/12, pp.490 - 512

Published online: 30 May 2025 *

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