Title: Synthesis of nanoparticles of quinoline derivatives and study of their antibacterial properties

Authors: Shaimaa Haidar Rabah

Addresses: College of Science, Al-Kharkh University of Science, Baghdad, Iraq

Abstract: Quinoline is an important natural alkaloid and its derivatives have great pharmaceutical importance. In this paper, the antibacterial and the effects of nanostructure of quinoline derivatives were studied. Four derivatives were synthesised from 8-amino quinoline by diazotisation reaction with acetophenone derivatives, and then bisthiazylthioether was synthesised in one step. The resulting compounds were characterised by: H-NMR, MS, and IR spectroscopy. Nanoparticles were synthesise by the sol-gel method and ultrasound together. The nanoparticles are spherical in clusters of similar sizes (less than 50 nm by scanning electron microscope images (SEM)). In X-ray diffraction (XRD), the crystals of the prepared nanomaterials were smaller than the particles (less than 20 nm) with small crystallinity percentages of less than 5%. The antibacterial of compounds and their nanoparticles were studied and compared with ampicillin. Nanoparticles have shown antibacterial activity several times greater than the effectiveness of corresponding solutions.

Keywords: quinoline; thioetherthiazyl; diazotisation; organic nanoparticles; sol-gel method; have antibacterial activity.

DOI: 10.1504/IJNBM.2024.143837

International Journal of Nano and Biomaterials, 2024 Vol.10 No.4, pp.301 - 310

Received: 19 Feb 2024
Accepted: 22 Jul 2024
Published online: 09 Jan 2025 *

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