Title: Development of silver nanoparticles using trigonella foenum graecum leaf extract and evaluation of their antimicrobial and noncytotoxic efficacy for dental applications

Authors: Lata S. Mushannavar; Ramesh K. Nadiger; M.Y. Kariduraganavar; Kiran Kumar Neelakantappa; Sachin Hegde

Addresses: Department of Prosthodontics, SDM College of Dental Sciences and Hospital, Sattur, Dharwad, 580009, Karnataka, India ' Department of Prosthodontics, SDM College of Dental Sciences and Hospital, Sattur, Dharwad, 580009, Karnataka, India ' Department of Chemistry, Karnatak University, Dharwad, 580003, Karnataka, India ' Department of Conservative Dentistry, Government Dental College and Research Institute, Bengaluru, 560002, Karnataka, India ' Department of Chemistry, Karnatak University, Dharwad, 580003, Karnataka, India

Abstract: This study explores the use of nanotechnology in addressing the emerging challenges of denture-related infections, particularly denture stomatitis, which is prevalent among geriatric patients with limited manual dexterity. The objective is to develop new bioactive compounds to combat microbial resistance. Silver nanoparticles were synthesised using an extract derived from Trigonella foenum graecum and characterised using various techniques. The antimicrobial activity of the nanoparticles against key microorganisms associated with denture stomatitis was evaluated, along with their cytotoxic effects on fibroblast cell lines. The results demonstrated that the synthesised nanoparticles exhibited high effectiveness against the tested microorganisms while displaying no significant cytotoxicity at bactericidal doses. These findings suggest that silver nanoparticles have substantial potential as antimicrobial additives in the fabrication process of acrylic dentures.

Keywords: silver nanoparticles; denture stomatitis; trigonella foenum graecum; antimicrobial activity; cytotoxicity.

DOI: 10.1504/IJNP.2023.135770

International Journal of Nanoparticles, 2023 Vol.15 No.1, pp.68 - 85

Received: 25 Oct 2022
Accepted: 12 Oct 2023
Published online: 04 Jan 2024 *

Full-text access for editors Full-text access for subscribers Purchase this article Comment on this article