Title: New nanoparticle computed tomography contrast agent in the treatment of neonatal hypoxic-ischemic encephalopathy

Authors: Yulin Chen; Wei Liu; Jingwei Sun; Linbao Wen

Addresses: Anesthesia Surgery Center, Taian City Central Hospital, Taian, 271000, China ' Anesthesia Surgery Center, Taian City Central Hospital, Taian, 271000, China ' Department of Neurosurgery, The Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang 550003, China ' Department of Neurosurgery, The Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang 550003, China

Abstract: This study uses the preparation of iodine-containing polymer nanoparticles contrast agent by precipitation polymerisation method, used in the diagnosis of head CT in children with HIE, and analysed the CT manifestations of children with HIE. The article selected 36 children with HIE admitted from January 2019 to December 2020 as the observation group. In addition, we selected 36 patients who were born at the same time and had clinical symptoms but no abnormalities in CT examination as the control group. The brain CT value of the severe group was lower than that of the moderate group and the mild group, and the difference was statistically significant (P < 0.05). For this reason, we have concluded that cranial CT examination with iodine-containing polymer nanoparticles as a contrast agent can reflect the scope, location and extent of neonatal ischemic and hypoxic encephalopathy, and has guiding significance for early diagnosis and treatment.

Keywords: head CT performance; new nanoparticles; iodine-containing polymer nanoparticles; hypoxic-ischemic encephalopathy; clinical.

DOI: 10.1504/IJNT.2022.128967

International Journal of Nanotechnology, 2022 Vol.19 No.6/7/8/9/10/11, pp.874 - 884

Received: 30 Apr 2021
Accepted: 08 Jul 2021
Published online: 13 Feb 2023 *

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