Title: Nano-targeted drugs in combined treatment and nursing of liver cancer

Authors: Lan Li; Tingting Qiu; Yuqin Ni

Addresses: Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072, China ' Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072, China ' Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072, China

Abstract: This paper uses the new polymer material N-glycyrrhetinic acid (GA)-polyethylene glycol (PEG)-chitosan (NGPC) as the carrier material, and uses the ion cross-linking method to prepare Brucine-loaded chitosan nanoparticles (Brucine/NGPC-NPs). The uptake of Brucine solution and Brucine/NGPC-NPs by hepatocellular carcinoma cells is both time- and concentration-dependent. The uptake of NGPC-NPs is significantly stronger than that of solution. It has significant active transport characteristics, and the intake follows the order of exogenous licorice. The addition of acid decreases, and its uptake pathway mainly depends on clathrin-mediated endocytosis and then internalisation by the cell. Therefore, we can conclude that NGPC-NPs can be used as a carrier for liver cell targeting, significantly increasing the amount of drugs entering liver cancer cells, and achieving the purpose of reducing toxicity and increasing efficiency.

Keywords: Brucine; nano-targeted drugs; chitosan nanoparticles; liver cancer cells; cell uptake; liver cancer care.

DOI: 10.1504/IJNT.2022.128966

International Journal of Nanotechnology, 2022 Vol.19 No.6/7/8/9/10/11, pp.851 - 860

Received: 30 Apr 2021
Accepted: 06 Jul 2021
Published online: 13 Feb 2023 *

Full-text access for editors Full-text access for subscribers Purchase this article Comment on this article