Title: Polyacrylic acid coated nanomaterials and sports rehabilitation training on the therapeutic effect of patients with stroke

Authors: Dan He; Yu Bai

Addresses: Changzhou No. 2 People's Hospital, Changzhou, Jiangsu, 213000, China ' Changzhou No. 2 People's Hospital, Changzhou, Jiangsu, 213000, China

Abstract: This paper explores the protective effect of alteplase-loaded dextran-polyacrylic acid nanoparticles on hippocampal neurons in stroke rats. We randomly divided 24 stroke rats into sham operation group, stroke group, stroke + alteplase group, stroke + alteplase-loaded dextran-polyacrylic acid nanoparticle intervention group. We used the HE stains method to detect the number of neurons in the hippocampus and calculate the survival rate of neurons under an inverted microscope. The survival rates of neurons in the sham operation group, stroke group, alteplase group, and nanoparticle group were 100%, 11.0%, 16.6%, and 57.6%. The ischemic encephalopathy group and the neuron survival rates of the general enzyme group and the nanoparticle group were lower than that of the sham operation group. The neuron survival rate of the nanoparticle group was higher than that of the stroke group and alteplase group (P < 0.05). There was no statistical difference between the alteplase group and the stroke group.

Keywords: stroke; polyacrylic acid nanoparticles; exercise rehabilitation; alteplase; therapeutic effect.

DOI: 10.1504/IJNT.2022.128963

International Journal of Nanotechnology, 2022 Vol.19 No.6/7/8/9/10/11, pp.577 - 586

Received: 03 May 2021
Accepted: 18 Jun 2021
Published online: 13 Feb 2023 *

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