Title: Adoption of porous nanocomposite fibre scaffold in cartilage injury healing and rehabilitation

Authors: Jucui Wang; Mingzhi Li

Addresses: Department of Physical Education, North China Institute of Science and Technology, Hebei, 065201, China ' Department of Physical Education, North China Institute of Science and Technology, Hebei, 065201, China

Abstract: To evaluate the effect of porous nanofibre scaffold on the healing and repair of cartilage defects in animal models, three different PNFSs were prepared, namely gelatin/polylactic acid scaffold, thermally cross-linked Gel/PLA scaffold, and hyaluronic acid modified Gel/PLA-T scaffold. The characterisation of scaffolds was implemented. Bone marrow stromal cells were taken as the research object, and the detection of cell proliferation and apoptosis was performed to evaluate the biocompatibility of each scaffold after scaffold was co-cultured with cells. A New Zealand rabbit model of cartilage defect was constructed. It showed that the density, mechanical properties, and in vitro degradation rate of HA@Gel/PLA-T scaffolds were remarkably increased relative to Gel/PLA and Gel/PLA-T scaffolds, while the porosity and water absorption rate decreased(P<0.05). It was verified that the prepared HA@Gel/PLA-T composite PNFS can promote the proliferation and chondrogenic differentiation of BMSCs cells, thereby promoting the repair and regeneration of cartilage damaged tissues.

Keywords: nanofibre scaffold; cartilage defect; wound healing; chondrogenic differentiation; injury rehabilitation.

DOI: 10.1504/IJNT.2022.128961

International Journal of Nanotechnology, 2022 Vol.19 No.6/7/8/9/10/11, pp.504 - 521

Received: 29 Apr 2021
Accepted: 02 Jun 2021
Published online: 13 Feb 2023 *

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