Title: Histopathological and biochemical correlation of antidiabetic activity of zinc oxide nanoparticles after oral administration in Wistar rats

Authors: Shrish Vijaykumar Raut; Gauri Rajendra Kulkarni; Chandrashekhar Sambhaji Mote

Addresses: School of Basic Medical Sciences, Savitribai Phule Pune University, Ganeshkhind Road, Pune 411007, Maharashtra, India ' School of Basic Medical Sciences, Savitribai Phule Pune University, Ganeshkhind Road, Pune 411007, Maharashtra, India ' Department of Pathology, Krantisinh Nana Patil College of Veterinary Science, Shirwal, Satara – 412801, Maharashtra, India

Abstract: Nanomaterials have high surface-to-volume ratios and possess unique physiological and biochemical properties modulating a wide range of reactions causing inflammation and cell toxicity. The present work was aimed to evaluate histopathological and biochemical changes in organs of the glucose metabolism after treatment with zinc oxide nanoparticles (ZnONP) in diabetic Wistar rats. Induction of diabetes was done with Streptozotocine and animals were treated with ZnONP in three graded doses in different groups. Glipizide was added in standard treatment and one of the ZnONP groups. Overall histopathological changes were observed as mild to moderate in diabetic animals that received no treatment and minimal in those that received standard treatment as Glipizide. The animals that received ZnONP as a treatment showed minimal to no abnormality detected on histopathology. Biochemical analysis revealed that ZnONP possess antidiabetic and lipid lowering activity which was consistent with histopathology. It is concluded that ZnONP play pivotal role in glucose metabolism and should be investigated further so that they can be introduced into diabetes treatment.

Keywords: zinc oxide nanoparticles; antidiabetic activity; histopathology; pancreas.

DOI: 10.1504/IJBNN.2020.116334

International Journal of Biomedical Nanoscience and Nanotechnology, 2020 Vol.4 No.3/4, pp.222 - 234

Received: 19 Sep 2020
Accepted: 16 Dec 2020
Published online: 20 Jul 2021 *

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