Title: Bioactivity studies of an endangered medicinal plant Celastrus paniculatus willd.: an overview

Authors: Bhagyashree Biswal; Biswajit Jena; Alok Kumar Giri; Laxmikanta Acharya

Addresses: Molecular Biology and Genetic Engineering Lab, Centre for Biotechnology, School of Pharmaceutical Sciences, Siksha 'O' Anusandhan (Deemed to be University), Bhubaneswar, Odisha – 751003, India ' Molecular Biology and Genetic Engineering Lab, Centre for Biotechnology, School of Pharmaceutical Sciences, Siksha 'O' Anusandhan (Deemed to be University), Bhubaneswar, Odisha – 751003, India ' Molecular Biology and Genetic Engineering Lab, Centre for Biotechnology, School of Pharmaceutical Sciences, Siksha 'O' Anusandhan (Deemed to be University), Bhubaneswar, Odisha – 751003, India ' Molecular Biology and Genetic Engineering Lab, Centre for Biotechnology, School of Pharmaceutical Sciences, Siksha 'O' Anusandhan (Deemed to be University), Bhubaneswar, Odisha – 751003, India

Abstract: Celastrus paniculatus willd., an extremely versatile medicinal plant, is commonly used as memory sharpener, anti-depressant, rejuvenant, nervine tonic, free radical scavenger, anti-oxidant etc. The present review is made to enlighten the information based upon scientific evidence regarding morphological description, pharmacological actions and phytoconstituents of this plant. The leaves of the plant show significant anti-fungal and anti-microbial activity. The root bark exhibited antimalarial activity while seed shows sedative, antidepressant, antifertility and wound healing activity. These plants are naturally used for treatment of blood purification after delivery, menstruation cycle and abortion. Due to the wide range of medicinal properties, the plant is being harvested erratically from wild coupled with cultivars; the species is listed as endangered and a vulnerable medicinal plant. Hence, realising the importance of the plant and the current threat to its existence, more scientific effort is required for conservation and efficient propagation for this plant to meet the growing demand.

Keywords: Jyotishmati; RAPD; random amplified polymorphic DNA; ISSR; ınter simple sequence repeats; pristimerin; memory enhancer; Lupeol; antimicrobial; celastrine; malkanguniol; celastrol; antidepressant.

DOI: 10.1504/IJGENVI.2020.115884

International Journal of Global Environmental Issues, 2020 Vol.19 No.4, pp.354 - 375

Received: 16 May 2019
Accepted: 06 Jan 2020

Published online: 05 Jul 2021 *

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