Title: Application and research of nano-biomaterials in repair and treatment of sports ligament injury

Authors: Zixuan Ye; Lan Zhou; Youshen Cao

Addresses: Department of Sports, Northwest University, Xi'an, 710127, China ' Department of Sports, Northwest University, Xi'an, 710127, China ' College of Arts and Sports, Dong-A University, Busan, 49315, South Korea

Abstract: A total of 18 male New Zealand white rabbits aged 3 months were selected for operation by using horse serum combined with Dimi rabbit femoral head necrosis model. After finishing the modelling, the rabbits that were successfully modelled were randomly divided into equal groups and divided into the following three groups: the autogenous bone group (group A), the stent group (group B), and the right-guidance combined stent group (Group C), there are six animals in each group. At the same time, they were treated with femoral head necrosis and hip-sparing surgery, and they were all located on the right side. Group A had autologous patella repair material, group B tricalcium phosphate scaffold, and group C right-guiding gavage combined with phosphate implantation. Three calcium scaffolds. From the beginning of the surgery, rabbits in each group were sacrificed on the 5th, 10th, and 15th weeks by over-anaesthesia, and the three groups were examined by histology and immunohistochemistry. Through research, Youguiyin combined with stent has a significant effect on the repair of wrist and femoral head necrotic bone, promotes osteogenesis and inhibits osteoclastic activity, and significantly improves the ability of bone repair in the head. Youguiyin can further improve the stent implantation. Stent osseointegration ability is a good alternative to autologous bone, and it provides some ideas for exploring new methods of integrated traditional Chinese and Western medicine for repairing wrist ligament damage.

Keywords: nano-biomaterials; wrist joint; ligament injury; sports rehabilitation; nanotechnology.

DOI: 10.1504/IJNT.2021.114224

International Journal of Nanotechnology, 2021 Vol.18 No.1/2/3/4, pp.184 - 199

Received: 08 May 2021
Accepted: 12 May 2021

Published online: 02 Apr 2021 *

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