Authors: Lihong Zhang; Jianfeng Yang
Addresses: P.E. Department, Xingtai Polytechnic College, Xingtai, 054000, China ' College of Physical Education, Xingtai University, Xingtai, 054001, China
Abstract: The ankle joint is an important weight-bearing joint of the lower limbs. It converts the vertical gravity of the human body into an arched structure. When the ankle joint is exposed to external reaction forces and cannot be effectively cushioned, injuries can easily occur. If improper and untimely treatment can cause joint instability, easy to repeatedly sprain in the future, secondary joint adhesions or traumatic arthritis can cause dysfunction. Therefore, strengthening the treatment of ankle joint injury repair is of great significance to improve prognosis and improve clinical effect. Clinically, the treatment of ankle joint injury is mainly based on protection, rest, cold compress, and drug intervention. It is difficult to achieve the expected therapeutic effect. From a large amount of research data, with the development of tissue engineering and bioengineering, currently the use of artificial biological materials to intervene in the healing and rehabilitation of bone injuries has become increasingly mature, but it is relatively rare in rehabilitation measures for ankle sports injuries. Therefore, in this study, 3D printing technology was used to mix PHBV, calcium silicate, and bioactive glass to successfully prepare a bioglass scaffold BG-Si-PHBV. The micromorphology, porosity, water absorption, weight loss analysis and biomechanical characteristics of the biomaterial scaffold were studied. At the same time, this study established an ankle joint sports injury model with Beagle dogs, implanted BG-Si-PHBV biological bone tissue scaffold material into the ankle joint defect area of the affected limb of Beagle dogs, and detected BG-Si-PHBV tissue engineering materials to repair the ankle joint Feasibility of sports injuries. The BG-Si-PHBV biological bone tissue scaffold material prepared in this research has good porosity, hydrophilicity and biomechanical properties, which can meet the conditions of artificial biological materials after ankle injury. Animal experiments show that BG-Si-PHBV biological bone tissue scaffold is ideal for the rehabilitation of ankle joint sports injuries. This helps to improve the biomechanical properties and has broad application prospects.
Keywords: nano-biomaterials; bioglass-Si-PHBV bone tissue scaffold; ankle sports injury repair; artificial bone rehabilitation; biomedicine.
International Journal of Nanotechnology, 2021 Vol.18 No.1/2/3/4, pp.156 - 170
Received: 08 May 2021
Accepted: 12 May 2021
Published online: 02 Apr 2021 *