Title: Application of rehabilitation of cruciate ligament injury during exercise based on nano-biomaterials tissue engineering treatment plan

Authors: Yingjie Shi

Addresses: Department of Physical Education, Henan Institute of Economics and Trade, Zhengzhou, 450000, China

Abstract: The development and application of biomaterial tissue engineering technology provide new ideas and approaches in the rehabilitation of a cruciate ligament injury. Polyvinyl alcohol (PVA) fibre meets biosafety requirements, has no toxicity, no irritation, no genotoxicity, no carcinogenicity, and good biocompatibility to the human body. This study investigated and verified the growth of the human anterior cruciate ligament (hACL) cells on the ligament scaffold material PVA. This study shows that a PVA fibre as a tissue engineering scaffold ligament, cultured hACL cells in vitro proliferative capacity and a strong ability to secrete collagen matrix. The scaffold material has good cell compatibility, has certain swelling and mechanical properties, and is expected to develop into an ideal tissue for engineering anterior cruciate ligament scaffold material for rehabilitation treatment of a cruciate ligament injury during exercise.

Keywords: human anterior cruciate ligament; tissue engineering; scaffold material; mechanical properties; cell compatibility; nano-biomaterials; PVA; polyvinyl alcohol.

DOI: 10.1504/IJNT.2021.114219

International Journal of Nanotechnology, 2021 Vol.18 No.1/2/3/4, pp.113 - 126

Received: 08 May 2021
Accepted: 12 May 2021

Published online: 01 Apr 2021 *

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