Title: Investigation of the effectiveness of biosynthesised gold nanoparticle from Garcinia kola leaves against fungal infections

Authors: Folorunso Femi Adekunle; Folorunso Aderonke Similoluwa; Akintelu Sunday Adewale

Addresses: Department of Anatomy, Osun State University, Osogbo, Nigeria ' Department of Chemistry, Louisiana State University, Louisiana, USA ' Department of Pure and Applied Chemistry, Ladoke Akintola University of Technology, Ogbomoso, Nigeria

Abstract: This research centred on the evaluation of the antifungal potency of gold nanoparticles (AuNPs) synthesized from Garcinia kola leaves. The leaves of Garcinia kola obtained were thoroughly rinsed, air dried, pulverized and extracted. The extract obtained was mixed with aqueous solution of gold chloride to form gold nanoparticle and were characterized. The antifungal screening of the synthesized gold nanoparticles was carried out via the Agar disc diffusion method. The ultraviolet (UV) analysis showed an absorption wavelength at 536.12 nm. The scanning electron microscopic (SEM) image confirmed uniform distribution of the synthesized gold nanoparticles. The transmission electron microscope (TEM) analysis confirmed that the particle size are in the range of 8.21 to 19.00 nm. The broad inhibitory zones against test fungi displayed by the synthesized nanoparticles confirmed the synthesized gold nanoparticles as a good antifungal source. This study establish a simple, easy and environmental friendly approach of synthesizing gold nanoparticles.

Keywords: Garcinia kola leaf; gold nanoparticle; antifungal activity; medicinal plants.

DOI: 10.1504/IJNP.2020.112402

International Journal of Nanoparticles, 2020 Vol.12 No.4, pp.316 - 326

Received: 13 Dec 2019
Accepted: 13 Feb 2020
Published online: 14 Jan 2021 *

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