Title: Non-invasive assessment of fractional flow reserve using computational fluid dynamics modelling from coronary angiography images

Authors: A. Udaya Kumar; R. Raghavi; R. Reshma; S.P. Angeline Kirubha

Addresses: Biomedical Engineering Department, School of Bioengineering, Faculty of Engineering and Technology, SRM Institute of Science and Technology, Chennai, India ' Biomedical Engineering Department, School of Bioengineering, Faculty of Engineering and Technology, SRM Institute of Science and Technology, Chennai, India ' Biomedical Engineering Department, School of Bioengineering, Faculty of Engineering and Technology, SRM Institute of Science and Technology, Chennai, India ' Department of Biomedical Engineering, SRM University, Chennai, India

Abstract: Fractional flow reserve (FFR invasive) is measured by measuring pressure differences across a coronary artery stenosis by coronary catheterisation technique. This is a gold standard method of determining the extent of stenosis. This method has some potential complications such as coronary vessel dissection, embolism, and renal failure. This paper presents a method for an assessment of FFR noninvasively, with coronary CT angiography imaging and fluid dynamics modelling. FFR is calculated as the ratio between pressure distal to stenosis and pressure proximal to stenosis of the coronary artery region segmented from CT angiography image using MIMICS software. ANSYS software is used to determine the FFR (0.73 ± 0.14). FFR can also be computed non-invasively by this technique for other cardiovascular conditions related to peripheral, cerebrovascular and renovascular disease.

Keywords: coronary CT angiography; computational fluid dynamics; fractional flow reserve; MIMICS; ANSYS.

DOI: 10.1504/IJMEI.2021.111863

International Journal of Medical Engineering and Informatics, 2021 Vol.13 No.1, pp.44 - 53

Received: 20 Jul 2018
Accepted: 12 Feb 2019
Published online: 18 Dec 2020 *

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