Title: DNA nanoparticles for gene delivery to cells and tissue

Authors: Hossein Hosseinkhani

Addresses: International Center for Young Scientists, National Institute for Materials Science, 1-1 Namiki, Tsukuba, 305 0044 Ibaraki, Japan

Abstract: The development over the past decade of methods for delivering genes to mammalian cells has stimulated great interest in the possibility of treating human disease by gene-based therapies. The major aim of gene therapy is to effectively deliver the genetic materials into cells, genetically modifying and repairing cell functions, which may induce therapeutic healing of disease conditions. This review provides a critical view of gene therapy with a major focus on advanced DNA nanoparticles technologies to control the in vivo location and function of administered genes.

Keywords: gene therapy; viral vectors; non-viral vectors; plasmid DNA; gene expression; DNA nanoparticles; gene delivery; nanotechnology; mammalian cells; disease treatment; gene transfection.

DOI: 10.1504/IJNT.2006.011172

International Journal of Nanotechnology, 2006 Vol.3 No.4, pp.416 - 461

Published online: 20 Oct 2006 *

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