Title: In-silico analysis of PON1, PON2 and PON3 genes role in coronary artery disease

Authors: Sana Ashiq; Kanwal Ashiq

Addresses: Centre of Applied Molecular Biology (CAMB), University of the Punjab, Lahore, 53700, Pakistan ' Faculty of Pharmaceutical Sciences Superior College, Superior University, 17-km Raiwind Road, Lahore, 55150, Pakistan

Abstract: Purpose: Globally coronary artery disease (CAD) is a leading cause of mortality. It is a multifactorial disorder which involves both environmental and genetic factors. This study aimed at in-silico analysis of the PON gene family and its role in the CAD. Methods: Several computational tools included National Centre for Biotechnology Information (NCBI), Uniprot, Expasy, ProtParam, Gene Card, Protein Data Bank (PDB) and PDBSUM used for in-silico analysis. Results: The gene card analysis illustrates its association with different lipoproteins. The PDB results showed three dimensional structure and its ligands interaction. Further, by using PDBSUM its interaction with ligands was studied and two major ligands one is phosphate and other is dodecyl-betad-maltoside were identified. Conclusion: The present study reports various ligands which interact with gene at different positions and support its association with lipoproteins. The study outcomes can help in better understanding of the pathophysiology of CAD and in the drug designing.

Keywords: CAD; coronary artery disease; genes; in-silico; paraoxonase; single nucleotide polymorphisms.

DOI: 10.1504/IJCBDD.2020.111057

International Journal of Computational Biology and Drug Design, 2020 Vol.13 No.4, pp.415 - 423

Received: 14 May 2020
Accepted: 03 Jul 2020
Published online: 06 Nov 2020 *

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