Title: Multiobjective Pareto optimisation of pharmaceutical product formulation using radial basis function network and non-dominated sorting differential evolution
Authors: J. Satya Eswari; Ch. Venkateswarlu
Addresses: Department of Biotechnology, National Institute of Technology, Raipur, 492001, India ' Chemical Engineering Department, Padmasri Dr. BV Raju Institute of Technology, Narsapur, 502313, India
Abstract: Pharmaceutical product formulation often involves several composition factors and response characteristics and its optimal formulation requires the best combination of formulation variables to satisfy the multiple and conflicting characteristics of the product. In this work, a novel multiobjective Pareto optimisation strategy is developed by combining a radial basis function network (RBFN) with a non-dominated sorting differential evolution (NSDE) and applied for optimal formulation of a trapidil product involving conflicting response characteristics. The RBFN models of this strategy are developed by using spherical central composite design data of trapidil formulation variables representing the amounts of microcrystalline cellulose, hydroxypropyl methylcellulose and compression pressure and the corresponding response data of release order and rate constant. These models in combination with NSDE are augmented with naïve and slow and constraint techniques to generate Pareto optimal solutions for product formulation. The optimal formulation results of RBFN-NSDE are compared with those of multiple regression model-based evolutionary Pareto optimisation strategy. The RBFN-NSDE is found to exhibit better Pareto optimal performance for pharmaceutical product formulation.
Keywords: pharmaceutical formulation; multiple regression model; response surface method; radial basis function network; RBFN; differential evolution; multiobjective optimisation.
International Journal of Biomedical Engineering and Technology, 2020 Vol.33 No.2, pp.95 - 122
Received: 12 Mar 2017
Accepted: 04 Sep 2017
Published online: 05 Jun 2020 *