Title: Radial basis function neural network with genetic algorithm for discrimination of recombination hotspots in saccharomyces cerevisiae

Authors: Ashok Kumar Dwivedi

Addresses: Department of Bioinformatics, Mathematics and Computer Applications, Maulana Azad National Institute of Technology, Bhopal, 462003, M.P., India

Abstract: Recombination influences the evolution of saccharomyces cerevisiae. Genomic regions where recombinations occurs are known as recombination hotspots. There are two kind of hotspots for recombination. The spots where recombination occurs more frequently are called recombination hot spots and regions where recombination occurs less frequently are known as cold spots. In this work, we have formulated methods based on neural network models for the classification of these hot and cold recombination spots on the basis of compositional features of nucleotide sequences. These models were validated using tenfold cross validation technique. The classification accuracy of 83%, 82%, and 78% were achieved using radial basis function neural network with genetic algorithm, radial basis function neural network and multilayer perceptron models respectively. Moreover, the performance of these model were evaluated on different ct classification measurements. Furthermore, results indicate that redial basis function neural network with genetic algorithm gives best result.

Keywords: artificial neural network; ANN; radial basis function neural network RBFNN; genetic algorithm; multi-layer perceptron; MLP; classification; machine learning; evolution.

DOI: 10.1504/IJMEI.2020.106895

International Journal of Medical Engineering and Informatics, 2020 Vol.12 No.2, pp.108 - 118

Received: 25 Jul 2017
Accepted: 24 May 2018
Published online: 27 Apr 2020 *

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