Title: Tumour cells and life expectancy: an exergy approach

Authors: Izabela Batista Henriques; Silvio De Oliveira Junior

Addresses: Polytechnic School of the University of São Paulo, Av. Prof. Mello Moraes, 2231, 05508-900, São Paulo, Brazil; Mechanical Engineering Division of the Aeronautics Institute of Technology, Marechal Eduardo Gomes Sq., 50, 12228-900, São José dos Campos, SP, Brazil ' Polytechnic School of the University of São Paulo, Av. Prof. Mello Moraes, 2231, 05508-900, São Paulo, Brazil

Abstract: In the present work, the rate of living theory and exergy analysis are gathered to assess the effects of cancer on life expectancy. An exergy model of a cancer cell metabolism is proposed taking into account the changes in the metabolic paths. Results indicate a threefold increase in the rate of exergy metabolism of a cancer cell. Moreover, per mole of glucose, a cancer cell obtains 8.9 moles of ATP against 32 synthesised by a healthy one. However, because of the increase in the rate of glucose uptake, the metabolic routes of the tumour are less efficient but are faster. The analysis of a generic tumour progression indicates that, in the absence of treatment, survival time would be around three years. Furthermore, in case of complete removal of the tumour, every six months living with the disease would lead to a reduction of almost four years in life expectancy.

Keywords: exergy destruction; metabolism; cancer; life expectancy.

DOI: 10.1504/IJEX.2020.105478

International Journal of Exergy, 2020 Vol.31 No.2, pp.103 - 119

Received: 19 Mar 2019
Accepted: 18 Aug 2019

Published online: 24 Feb 2020 *

Full-text access for editors Access for subscribers Purchase this article Comment on this article