Title: Improving the nerve regeneration ability by inhibiting the orchestral activity of the myelin associated repair inhibitors: an in silico approach

Authors: Sumaira Kanwal; Shazia Perveen

Addresses: Department of Biosciences, COMSATS University Islamabad, Sahiwal Campus, 75500, Pakistan ' Department of Zoology, The Women University Multan, Matital Campus, 75500, Pakistan

Abstract: Nerve injuries plays a significant role in terms of individual's life style as it can be treatable or vice versa in context of the origin of the nerve. Unluckily, the repairing ability of the central nervous system is very restricted because of reduced intrinsic growth capacity, which is much feasible in PNS. These axonal growth inhibitory proteins are mediated via activation of Rho. In the present study, a hybrid approach of comparative modelling and molecular docking followed by inhibitor identification and structure modelling was employed. Our analysis showed that the two important drugs which are widely used have the potential to block the Rho-Rock pathways. Here, we report inhibitors which showed binding affinity for the three most important axonal regeneration inhibitors. Three step approaches can be used to defeat the axonal neuropathies that especially in the CMT disease. However further studies are required to find the applications of these drugs.

Keywords: axonapathy; CMT2; NOGO; rho-rock pathways; nonsteroidal anti-inflammatory drugs; neurological disorder; SCI; spinal cord injury; multiple sclerosis.

DOI: 10.1504/IJCBDD.2019.101058

International Journal of Computational Biology and Drug Design, 2019 Vol.12 No.3, pp.251 - 260

Received: 12 Jan 2018
Accepted: 29 May 2018
Published online: 23 Jul 2019 *

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