Title: Zeolite-biopolymer nanocomposites in bone tissue engineering

Authors: Rana Kafili Zangbar; Reza Manafzadeh; Ali Nivpour; Mehrdad Farahmandnejad; Saeid Sabzehali; Faezeh Ziyadini Dashtkhaki

Addresses: School of Metallurgical and Materials Engineering, Iran University of Science and Technology (IUST), Tehran, 1684613114, Iran ' Science and Research Branch, Islamic Azad University Central Tehran Branch, Tehran, 1941846131, Iran ' Faculty of Technology and Engineering, Imam Khomeini International University, Qazvin, 3414896818, Iran ' Department of Materials and Metallurgical Engineering, Amirkabir University of Technology, Tehran, 1591634311, Iran ' Faculty of Materials Engineering, Isfahan University of Technology, Isfahan, 8415683111, Iran ' Faculty of Technical, Shahid Bahonar University of Kerman, Kerman, 7616913439, Iran

Abstract: The field of tissue engineering is a combination of several fields to expand and use new materials for the treatment of tissue defects. Among materials with porous structures, zeolite with a wide range of pores as an effective biocompatible material can be used in the construction of bone tissue engineering scaffolds. The specific surface area of Nano zeolites is much higher than the specific surface area of micro zeolites and this additional surface area leads to more reactivity or functionalization. By combining zeolite with biopolymers, nanocomposites can be synthesized that are more similar to natural bone tissue than zeolite. The bioactive zeolite gives the nanocomposite scaffold strength and bone conductivity, while the polymeric matrix provides structural support for cell adhesion and subsequent cellular processes leading to tissue development. Therefore, in this study, the effect of using zeolite-biopolymer nanocomposites as bone tissue engineering scaffolds has been investigated.

Keywords: nanocomposites; zeolites; biopolymer; tissue engineering; nanozeolite; porous structures; polymeric matrix; scaffolds; bioactive; bone defects.

DOI: 10.1504/IJNBM.2025.149150

International Journal of Nano and Biomaterials, 2025 Vol.11 No.2, pp.115 - 130

Received: 01 Mar 2024
Accepted: 06 Oct 2024
Published online: 15 Oct 2025 *

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