Detecting slow-translating regions in E.coli
by Lalit Ponnala
International Journal of Bioinformatics Research and Applications (IJBRA), Vol. 6, No. 5, 2010

Abstract: We present an application of the spatial scan statistic to identifying clusters of slow-translating codons in E.coli. We use an estimate of the time taken to process each codon based on the availability of transfer RNA. We analyse our findings using experimental measurements, and provide support for a well-known hypothesis related to the process of protein production.

Online publication date: Fri, 07-Jan-2011

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