Modelling response of excitable cells induced by electromagnetic fields Online publication date: Sun, 12-Mar-2017
by Soheil Hashemi; Ali Abdolali
International Journal of Computational Biology and Drug Design (IJCBDD), Vol. 10, No. 1, 2017
Abstract: Prediction and targeting of neural stimulation need an accurate analysis to model the activity of the nervous system in the presence of electric field. In this paper, fundamental of neural activity modelling in the vicinity of electric field is explained. The analysis is derived using continuity equation and cable theory. Inaccuracy of the formulation in the literature is also discussed and modified analysis is introduced in detail. Non-destructive external stimulation by a coil stimulator is modelled and simulated by finite difference method. Stimulation performance vs. frequency and geometry of stimulator is discussed. Accurate and authentic neuronal modelling in the presence of induced electric field is deduced only by satisfying Maxwell equations. Unlike our proposed method, most of the researches have not considered this issue. Therefore, at very low frequency, stimulation results show more than 70% difference in calculating the threshold of excitability between the proposed method and the one in the literature.
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