Preparation of water soluble carbon nanotubes and assessment of their biological activity in embryonic zebrafish
by Adeniyi A. Adenuga; Lisa Truong; Robert L. Tanguay; Vincent T. Remcho
International Journal of Biomedical Nanoscience and Nanotechnology (IJBNN), Vol. 3, No. 1/2, 2013

Abstract: Carbon nanotubes (CNTs) are currently one of the most important classes of nanomaterials with unique properties sparking off numerous applications in many fields, including electronics, material science and medicine. However, applications of CNTs in medicine and other biological fields are hampered by their insolubility in aqueous media and concerns regarding toxicity. In this study, seven types of CNTs, including two single-walled, one double-walled, and four multi-walled, were evaluated for possible toxicological effects. Soluble CNTs were prepared by treatment with a mixture of acids (D₂SO₄ and DNO₃), washed with Milli-Q water and oven dried. Transmission electron microscopy, thermal gravimetric analysis, and other techniques were used to characterise the prepared CNTs. CNT toxicity was assessed using the embryonic zebrafish. Results showed that none of the CNTs studied caused significant adverse developmental effects. These results support the potential safe use of CNTs as components of indwelling medical devices and drug delivery tools.

Online publication date: Sat, 12-Jul-2014

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