Biochemical and histopathological alterations in kidney of rats chronically exposed to mild silver protein
by Patricia Noemí Quiroga; Adriana Emilce Piñeiro; Adriana Haydée Sassone; Juan Carlos Perazzo; Otmaro Enrique Roses
International Journal of Environment and Health (IJENVH), Vol. 6, No. 3, 2013

Abstract: Chronic administration to Wistar rats of Mild Silver Protein (MSP) to a dose of 222 mg Ag/kg/day in the drinking water for six months showed that the MSP produces argyria, with histopathological lesions in the kidney, the organ where silver accumulates. The histopathology of the kidney showed capillary damage, with alteration of the vascular wall, increased perivascular cellularity and area with focal haemorrhage. The studies in 'open field' were carried out after one, three and six months of treatment and did not show modifications in the pattern of spontaneous locomotor activity. Parameters such as uremia, creatininemia, phosphatemia, alkaline phosphatase, aspartate aminotransferase, alanino-aminotransferase, gamma-glutamyl transpeptidase and lactate dehydrogenase registered in plasma displayed normal values showing normal renal and hepatic functionality. The present results encourage the need for future research to elucidate the molecular pathophysiology and potential functional alterations sustained by the morphological changes found.

Online publication date: Tue, 21-May-2013

The full text of this article is only available to individual subscribers or to users at subscribing institutions.

Existing subscribers:
Go to Inderscience Online Journals to access the Full Text of this article.

Pay per view:
If you are not a subscriber and you just want to read the full contents of this article, buy online access here.

Complimentary Subscribers, Editors or Members of the Editorial Board of the International Journal of Environment and Health (IJENVH):
Login with your Inderscience username and password:

    Username:        Password:         

Forgotten your password?

Want to subscribe?
A subscription gives you complete access to all articles in the current issue, as well as to all articles in the previous three years (where applicable). See our Orders page to subscribe.

If you still need assistance, please email