Development neurotoxicity: implications of methylmercury research Online publication date: Fri, 24-Oct-2008
by Philippe Grandjean, Marian Perez
International Journal of Environment and Health (IJENVH), Vol. 2, No. 3/4, 2008
Abstract: The causes of neurodevelopmental disorders are mostly unknown. Exposure to certain chemicals during early foetal development can cause permanent brain injury at doses much lower than those that affect the adult brain. Recent epidemiological evidence on methylmercury has shown adverse effects at exposure levels previously thought to be safe. Major obstacles in this research field include non-specific neurobehavioural outcomes and imprecise exposure assessments that result in a bias towards the null. Epidemiological studies may therefore easily underestimate the risk, but they are nonetheless often considered with scepticism. Neurodevelopmental toxicity potentials of numerous other chemicals have not yet been documented to the same extent as mercury, and exposures are therefore not regulated to protect the developing brain. The experience on mercury toxicity suggests that a precautionary approach to potential developmental neurotoxicants is warranted.
Online publication date: Fri, 24-Oct-2008
If you are not a subscriber and you just want to read the full contents of this article, buy online access here.Complimentary Subscribers, Editors or Members of the Editorial Board of the International Journal of Environment and Health (IJENVH):
Login with your Inderscience username and password:
Want to subscribe?
A subscription gives you complete access to all articles in the current issue, as well as to all articles in the previous three years (where applicable). See our Orders page to subscribe.
If you still need assistance, please email email@example.com