Comparison of the structural features of botulinum neurotoxin and NTNH, a non-toxic accessory protein of the progenitor complex
by Kristine M. Krebs, Frank J. Lebeda
The Botulinum J. (TBJ), Vol. 1, No. 1, 2008

Abstract: The non-toxic, non-hemagglutinin (NTNH) protein occurs with the seven progenitor serotypes of the botulinum neurotoxins (BoNTs). Bioinformatic techniques predict that the N- and C-termini of NTNH have the same folds as the corresponding domains of BoNT. In contrast, the sequence pattern for zinc-binding in the catalytic domain of BoNT is absent in NTNH. The intermediate domain of NTNH is predicted to have neither the coiled-coil nor the hydrophobic characteristics of the corresponding region of BoNT. BoNT and NTNH are hypothesised to have diverged in their amino acid sequences from a common ancestor which accounts for their structural and functional differences. [Received 24 October 2007; Accepted 21 November 2007]

Online publication date: Wed, 25-Jun-2008

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