Evaluation of endothelial response to reactive hyperaemia in peripheral arteries using a physiological model Online publication date: Fri, 14-Aug-2020
by Mohammad Habib Parsafar; Edmond Zahedi; Bijan Vosoughi Vahdat
International Journal of Biomedical Engineering and Technology (IJBET), Vol. 33, No. 4, 2020
Abstract: Non-invasive measurement of flow-mediated dilation (FMD) in the brachial artery for assessing endothelial function is costly and operator-dependent, limiting its application to research cases. In this paper, an approach based on a physiological model between normalized central blood pressure and finger photoplethysmogram is presented. Baseline model parameters are estimated using a genetic algorithm in 30 subjects consisting of ten normal blood pressure (BP), ten high-BP and ten elderly volunteers. Beat-to-beat fitness values after reactive hyperaemia are calculated using baseline (before cuff occlusion) data. Results show that stimulus-induced changes are fairly described with a first order dynamic. The time constant of this first order system is significantly larger for normal BP compared to high BP (p-value = 0.004) and elderly subjects (p-value = 0.01). Our findings hint to the potential of the proposed physiological, model-based approach for evaluating cardiovascular health using FMD.
Online publication date: Fri, 14-Aug-2020
If you are not a subscriber and you just want to read the full contents of this article, buy online access here.Complimentary Subscribers, Editors or Members of the Editorial Board of the International Journal of Biomedical Engineering and Technology (IJBET):
Login with your Inderscience username and password:
Want to subscribe?
A subscription gives you complete access to all articles in the current issue, as well as to all articles in the previous three years (where applicable). See our Orders page to subscribe.
If you still need assistance, please email firstname.lastname@example.org