Title: sleBioRepo: a gene expression compendium in systemic lupus erythematosus

Authors: Sungjin Park; Seungyoon Nam

Addresses: College of Medicine, Gachon University, Incheon 21565, South Korea ' Gachon Institute of Genome Medicine and Science, Gachon University Gil Medical Centre, Department of Genome Medicine and Science, College of Medicine, Gachon University, Incheon 21565, South Korea; Department of Life Sciences, Gachon University, Seongnam 13120, South Korea

Abstract: Systemic lupus erythematosus (SLE, "lupus"), is an autoimmune disease in which the human immune system attacks the body's own organs and tissues. However, SLE is very difficult to diagnose, mimicking numerous other conditions, and manually curated database for mRNA expression levels, and SLE association studies, have yet to be established. Here, we constructed a user-friendly database, "sleBioRepo," equipped with a graphical web interface, for simple browsing or searching differential gene expression between control and case groups. Data sets in our database cover 32 Gene Expression Omnibus (GEO) series, consisting of 2042 samples of diverse body tissues. Also, we provide demographics, and differentially expressed genes, of user-selected samples and genes, for the purpose of improving knowledge of this pathology. We assert that our database will serve as a comprehensive resource for mRNA biomarker studies, as well as for prioritising mRNAs, for functional validation in SLE, with likely extension to other diseases.

Keywords: SLE; systemic lupus erythematosus; lupus; curated database.

DOI: 10.1504/IJDMB.2018.098947

International Journal of Data Mining and Bioinformatics, 2018 Vol.21 No.4, pp.365 - 375

Received: 12 Jan 2019
Accepted: 28 Jan 2019

Published online: 30 Mar 2019 *

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