Title: DNA and radiobiological material bank of persons exposed to ionising radiation

Authors: M.B. Freidin, R.M. Takhauov, A.B. Karpov, E.O. Vasilyeva, I.A. Goncharova, P.V. Ivanina, E.V. Skobelskaya, E.V. Nemykina, I.A. Ten, G.B. Nekrasov, A.S. Izosimov

Addresses: The Seversk Biophysical Research Centre, Federal Department of the Medical Biological and Emergency Problems, Russian Ministry of Public Health and Social Development, Seversk, Russia. ' The Seversk Biophysical Research Centre, Federal Department of the Medical Biological and Emergency Problems, Russian Ministry of Public Health and Social Development, Seversk, Russia. ' The Seversk Biophysical Research Centre, Federal Department of the Medical Biological and Emergency Problems, Russian Ministry of Public Health and Social Development, Seversk, Russia. ' The Seversk Biophysical Research Centre, Federal Department of the Medical Biological and Emergency Problems, Russian Ministry of Public Health and Social Development, Seversk, Russia. ' The Seversk Biophysical Research Centre, Federal Department of the Medical Biological and Emergency Problems, Russian Ministry of Public Health and Social Development, Seversk, Russia. ' The Seversk Biophysical Research Centre, Federal Department of the Medical Biological and Emergency Problems, Russian Ministry of Public Health and Social Development, Seversk, Russia. ' The Seversk Biophysical Research Centre, Federal Department of the Medical Biological and Emergency Problems, Russian Ministry of Public Health and Social Development, Seversk, Russia. ' The Seversk Biophysical Research Centre, Federal Department of the Medical Biological and Emergency Problems, Russian Ministry of Public Health and Social Development, Seversk, Russia. ' The Seversk Biophysical Research Centre, Federal Department of the Medical Biological and Emergency Problems, Russian Ministry of Public Health and Social Development, Seversk, Russia. ' The Seversk Biophysical Research Centre, Federal Department of the Medical Biological and Emergency Problems, Russian Ministry of Public Health and Social Development, Seversk, Russia. ' The Seversk Biophysical Research Centre, Federal Department of the Medical Biological and Emergency Problems, Russian Ministry of Public Health and Social Development, Seversk, Russia

Abstract: The structure of the DNA and radiobiological material bank of the Seversk Biophysical Research Center is described. Workers of the Siberian Group of Chemical Enterprises (SGCE) and their relatives are the subjects of the storage. Cytogenetic analysis, including Gbanding, is being performed for the participants. Currently, the bank contains 700 DNA and blood samples of workers of SGCE, 123 DNA and blood samples of cancer cases, about 500 DNA samples of children from Seversk city, and 100 blood samples of SGCE workers who survived acute myocardial infarction. DNA and blood accumulation is still in progress, but by this time, it is ready for large scale scientific projects devoted to the study of the genetic basis of individual radiosensitivity and consequences of low dose irradiation effect on the human genome.

Keywords: DNA bank; Siberia; chemical workers; low dose irradiation; genetic basis; individual radiosensitivity; radiobiology; low radiation; Russia; cytogenetic analysis; blood samples; acute myocardial infarction; human genome; ionising radiation.

DOI: 10.1504/IJLR.2006.009523

International Journal of Low Radiation, 2006 Vol.2 No.3/4, pp.179 - 187

Available online: 17 Apr 2006 *

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