Title: 'Early' leukaemia effect in prolonged exposure with high doses

Authors: V.Yu. Soloviev, V.G. Semenov, N.A. Koshurnikova, M.V. Kravchenko, I.S. Kuznetsova, A.S. Chistopol'sky

Addresses: State Research Centre, Institute of Biophysics, Moscow, Russia. ' State Research Centre, Institute of Biophysics, Moscow, Russia. ' South-Ural Institute of Biophysics, Ozersk, Chelyabinsk region, Russia. ' State Research Centre, Institute of Biophysics, Moscow, Russia. ' South-Ural Institute of Biophysics, Ozersk, Chelyabinsk region, Russia. ' State Research Centre, Institute of Biophysics, Moscow, Russia

Abstract: Unique information from the medical dosimetric register of the IC |Mayak| personnel (SUrIBPh) was used relating to the starting period of the beginnings of the Russian nuclear branch, when the personnel were exposed to doses that exceeded all modern standards. Earlier (2–5 years after the beginning of exposure), the dynamics of leukaemia morbidity was found among the personnel exposed to cumulative doses exceeding 3–4 Sv during a relatively short time period (<5 years), in contrast to that adopted by UNSCEAR. In order to facilitate the evaluation and prediction of radiation induced leukaemia morbidity dynamics, a mathematical model option is proposed based on assumptions developed for a description of the process of consistent, stable mutations arising in target cells. Data being obtained or the LSS (DS86) cohort and those from the IC |Mayak| personnel register were used for estimation of the model parameters.

Keywords: medical dosimetric register; high doses; leukaemia; morbidity dynamics; mathematical model; Russia; nuclear safety; radiation exposure; radiobiology; carcinogenic agents.

DOI: 10.1504/IJLR.2006.009520

International Journal of Low Radiation, 2006 Vol.2 No.3/4, pp.275 - 284

Available online: 17 Apr 2006 *

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