Title: Bioinformatic analysis of envelope gene of the dengue type 3 prevalent in India from 2005 onwards and comparison with dengue type 1

Authors: Sumanta Dey; Ashesh Nandy; Papiya Nandy; Sukhen Das

Addresses: Theory Department, Centre for Interdisciplinary Research and Education, 404B Jodhpur Park, Kolkata 700068, West Bengal, India ' Theory Department, Centre for Interdisciplinary Research and Education, 404B Jodhpur Park, Kolkata 700068, West Bengal, India ' Theory Department, Centre for Interdisciplinary Research and Education, 404B Jodhpur Park, Kolkata 700068, West Bengal, India ' Centre for Interdisciplinary Research and Education, 404B Jodhpur Park, Kolkata 700068, West Bengal, India; Department of Physics, Jadavpur University, Kolkata 700032, West Bengal, India

Abstract: High incidence of dengue infection, particularly dengue serotypes 1 and 3, has been observed across India in the last few years with large number of fatalities. Since the surface situated envelope protein of the dengue virion is responsible for virus entry into the host cell, we have focused on the characterisation and analyses of the envelope gene with an aim to eventually develop inhibitors of the dengue virus. Two-dimensional graphical representations and phylogenetic relationships of the envelope gene show an inherent cross-national spread of the dengue virus. Moreover, hydropathy analysis shows amino acid compositional changes leading to morphological changes in the envelope protein and perhaps higher pathogenicity. We also found evidences of recombination-like events taking place in some of the genes of the full dengue type 3 genome. These observations serve to show the urgency of comprehensive genetic surveillance of the dengue virus to anticipate further damaging changes in the viral sequence.

Keywords: dengue envelope gene; dengue virus; envelope protein morphology; graphical representation; hydropathy analysis; phylogeny; recombination; transition-transversion ratios.

DOI: 10.1504/IJBRA.2018.094962

International Journal of Bioinformatics Research and Applications, 2018 Vol.14 No.4, pp.357 - 375

Received: 16 Jul 2016
Accepted: 13 Nov 2016

Published online: 26 Dec 2017 *

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