Title: Potential of photoplethysmogram for the detection of calcification and stenosis in lower limb

Authors: Neelamshobha Nirala; R. Periyasamy; Awanish Kumar

Addresses: Department of Biomedical Engineering, National Institute of Technology Raipur, NIT Raipur, G.E Road, Raipur 492001, Chhattisgarh, India ' Department of Biomedical Engineering, National Institute of Technology Raipur, NIT Raipur, G.E Road, Raipur 492001, Chhattisgarh, India ' Department of Biotechnology, National Institute of Technology Raipur, NIT Raipur, G.E Road Raipur 492001, Chhattisgarh, India

Abstract: Early detection of arterial stiffness (AS) and atherosclerosis in lower limb is useful for the detection of cardiovascular and diabetic foot diseases. We used photoplethysmogram for the screening of peripheral arterial disease (PAD), and detection of AS occurred due to calcification. The study included three different groups (15-normal subjects (group-1), 6-subjects with known calcification (group-2) and 13 PAD patients). Compared to group-1, we obtained a significant increase in rise-time (282.00 vs. 305.50, p value = 0.009) and area under rise-time (AUR) (71.075 vs. 76.085, p value = 0.041) in PAD group. Similarly in group-2 significant decreases in AUR (71.075 vs. 60.825, p value = 0.000), area under diastole (136.347 vs. 110.538, p value = 0.001), Area (209.729 vs. 170.202, p value = 0.000) and 'b/a' (0.697 vs. 0.933, p value = 0.020) ratio was obtained compared to group-1 and significant increase in these features were noted in comparison with PAD group. The present finding may aid in the detection of PAD and AS due to calcification and arrange proper treatments plan.

Keywords: Ankle brachial index (ABI); area under diastole (AUD); area under rise-time (AUR); medial artery calcification (MAC); peripheral arterial disease (PAD); photoplethysmography (PPG); rise-time (RT); second derivative of photoplethysmogram (SDPPG).

DOI: 10.1504/IJBRA.2018.092704

International Journal of Bioinformatics Research and Applications, 2018 Vol.14 No.3, pp.283 - 304

Received: 20 Jun 2017
Accepted: 02 Sep 2017

Published online: 07 Dec 2017 *

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