Title: Subspace module extraction from MI-based co-expression network

Authors: Sarmistha Deb; Priyakshi Mahanta; Dhruba K. Bhattacharyya; Malay Ananda Dutta

Addresses: Department of Computerscience and Engineering, Tezpur University, Tezpur, India ' Department of Computerscience and Engineering, Tezpur University, Tezpur, India ' Department of Computerscience and Engineering, Tezpur University, Tezpur, India ' Department of Computerscience and Engineering, Tezpur University, Tezpur, India

Abstract: Most of the existing methods in literature have used proximity measures in the construction of co-expression networks (CEN) consisting of functional gene modules. This work describes the construction of co-expression network using mutual information (MI) as a proximity measure with non-linear correlation. The network modules are extracted that are defined over a subset of samples. This method has been tested on several publicly available datasets and the subspace network modules obtained have been validated in terms of both internal and external measures.

Keywords: co-expression network; mutual information; network modules; topological property.

DOI: 10.1504/IJBRA.2018.092685

International Journal of Bioinformatics Research and Applications, 2018 Vol.14 No.3, pp.207 - 234

Accepted: 03 Sep 2016
Published online: 07 Dec 2017 *

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