Title: Iteration method for detecting disease genes in terms of the integration of the cellular compartment information with the protein-protein interaction data

Authors: Xiwei Tang; Wei Peng; Minzhu Xie

Addresses: School of Information Science and Engineering, Hunan First Normal University, Changsha 410205, China; College of Computer, National University of Defense Technology, Changsha 410073, China ' Computer Center, Kunming University of Science and Technology, Kunming 650500, China ' College of Physics and Information Science, Hunan Normal University, Changsha 410081, China

Abstract: Many computational approaches identify disease genes based on the protein-protein interaction (PPI) networks because of the principle 'Guilt-by-Associate'. However, the defects of the PPI data severely reduce the accuracy of the predicting methods. In the current study, a new framework called IMIDG is developed to identify causal genes for diseases. First, the reliability of the interactions among proteins is quantified by incorporating the subcellular localisation information into the human PPI networks and the weighted networks are built. Based on the weighted PPI networks, an iteration function is performed to score and rank the disease candidate genes. The leave-one-out crossing validation (LOOCV) and literature study method are used to test IMIDG, DADA and ToppNet algorithms. The areas under curves show that IMIDG outperforms DADA and ToppNet methods in prioritising disease candidate genes. Additionally, out of the 18 novel genes in the top 50 gene set, five genes are proved to be associated with colorectal cancer by the literatures, suggesting the remaining genes for further investigation.

Keywords: iteration method; subcellular localisation; protein-protein interaction; disease gene.

DOI: 10.1504/IJDMB.2017.088140

International Journal of Data Mining and Bioinformatics, 2017 Vol.18 No.4, pp.315 - 330

Received: 14 Sep 2017
Accepted: 17 Sep 2017

Published online: 21 Nov 2017 *

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