Title: EhPPTome: Entamoeba histolytica protein phosphotome database

Authors: Tamanna Anwar; Samudrala Gourinath

Addresses: School of Life Sciences, Jawaharlal Nehru University, New Delhi, India ' School of Life Sciences, Jawaharlal Nehru University, New Delhi, India

Abstract: Entamoeba histolytica, a gastrointestinal parasite, is the causative agent of human amoebiasis. Amoebiasis is a serious health threat to the developing world. Complete genomic sequence provides an opportunity to broadly understand the organism, as well as the proteins can be used as therapeutic targets. Protein phosphatases play an important role in regulation of any organism including this parasite, thus protein phosphatases are looked upon as potent therapeutic targets. To improve the understanding of protein phosphatases in E. histolytica, a dedicated database and web server 'EhPPTome' is developed that incorporates information about 250 protein phosphatases in E. histolytica. EhPPTome includes the classification of phosphatases into superfamily and families, its localisation, biological function and KEGG pathway. EhPPTome designed for easy data access, popular resources at other sites, e.g. UniProt and PDB, are dynamically linked. The EhPPTome website is available freely to the scientific community at http://202.41.10.46/EhPPTome/, and should be cited with the present publication as reference.

Keywords: protein phosphatases; phosphotome; E. histolytica; Entamoeba histolytica; EhPPTome database; phosphorylation; dephosphorylation; kinome; kinases; cellular signalling; post-translational modification; bioinformatics; therapeutic targets; classification; biological function; KEGG pathway; gastrointestinal parasites; amoebiasis; web server; freely-available database.

DOI: 10.1504/IJBRA.2017.083151

International Journal of Bioinformatics Research and Applications, 2017 Vol.13 No.2, pp.178 - 183

Received: 04 Mar 2016
Accepted: 07 Aug 2016

Published online: 21 Mar 2017 *

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