Title: Association of claudin family protein in human cancer types: a network approach

Authors: Majji Rambabu; J. Febin Prabhu Dass; Sivaraman Jayanthi

Addresses: Computational Drug Design Lab, School of Bio Sciences and Technology, VIT University, Vellore 632014, Tamil Nadu, India ' Bioinformatics Division, School of Bio Sciences and Technology, VIT University, Vellore 632014, Tamil Nadu, India ' Computational Drug Design Lab, School of Bio Sciences and Technology, VIT University, Vellore 632014, Tamil Nadu, India

Abstract: Claudin family proteins are the most important components of the tight junctions (TJs). They are highly encompassing in human carcinoma such as lung, ovarian, breast, etc. This study sought to find protein-protein interaction network and the expression profile of claudins. The network result indicates the importance of tight junction protein1 and tight junction protein3 interactions with the class of various claudins. Moreover, screening of the three expression profiles through the assistance of gene set enrichment analysis and it is further validated by enrichment map. Our report had identified that lung adenocarcinoma, ovarian and hepatocellular carcinoma are responsible genes in claudins. An extent to expression profiles the enrichment map revealed the possible set of claudins in various cancers. Enrichment map helps to practically portray the vast quality genes, for example results of gene expression profiles. In conclusion, this computational study on gene network can emphasise the identification of new gene targets.

Keywords: claudins networks; gene expression profiles; gene enrichment map; protein-protein interactions; PPIs; claudin family proteins; human cancer types; human carcinoma; lung adenocarcinoma; ovarian carcinoma; hepatocellular carcinoma; gene networks; bioinformatics; gene targets.

DOI: 10.1504/IJBRA.2017.083147

International Journal of Bioinformatics Research and Applications, 2017 Vol.13 No.2, pp.131 - 145

Received: 10 Dec 2015
Accepted: 25 Jul 2016

Published online: 21 Mar 2017 *

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