Title: Assessment of early and late DNA damages in interventional radiologists exposed to protracted low dose and dose rate of X-radiation

Authors: Safa Abdul Syed Basheerudeen; Sakina Murtaza; Venkateswarlu Raavi; M. Bhavani; Santhosh Joseph; T.R. Muralidharan; Perumal Venkatachalam

Addresses: Department of Human Genetics, College of Biomedical Science Technology and Research, Sri Ramachandra University, Porur, Chennai 600116, India ' Department of Human Genetics, College of Biomedical Science Technology and Research, Sri Ramachandra University, Porur, Chennai 600116, India ' Department of Human Genetics, College of Biomedical Science Technology and Research, Sri Ramachandra University, Porur, Chennai 600116, India ' Department of Human Genetics, College of Biomedical Science Technology and Research, Sri Ramachandra University, Porur, Chennai 600116, India ' Department of Neuro Interventional Radiology, Sri Ramachandra University, Porur, Chennai 600116, India ' Department of Cardiology, Sri Ramachandra University, Porur, Chennai 600116, India ' Department of Human Genetics, Sri Ramachandra University, Porur, Chennai 600116, India

Abstract: Occupational radiation exposures for interventionalists are considered as the highest received doses among medical practitioners and contributing a risk of DNA damage. A significantly higher γ-H2AX foci and unstable chromosomal aberrations (p > 0.001) was observed in Peripheral Blood Lymphocytes (PBL) of medical professionals when compared to healthy volunteers, whereas translocations did not show any difference. The results suggest that low-dose protracted radiation exposure can induce DNA damages in PBL and can get repaired or misrepaired and develop into chromosomal aberrations.

Keywords: interventional radiology; protracted exposure; low dose exposure; low radiation; chromosomal aberrations; gamma-H2AX; early damage; late damage; DNA damage; radiologists; X-rays; peripheral blood lymphocytes; PBL.

DOI: 10.1504/IJLR.2016.081452

International Journal of Low Radiation, 2016 Vol.10 No.3, pp.198 - 209

Received: 07 Aug 2015
Accepted: 20 Dec 2015
Published online: 09 Jan 2017 *

Full-text access for editors Full-text access for subscribers Purchase this article Comment on this article