Authors: Bal Ram Singh
Addresses: Botulinum Research Center, Institute of Advanced Sciences, 86-410 Faunce Corner Mall Road, Dartmouth, MA 02747, USA
Abstract: The highly toxic nature of botulinum neurotoxins and their placement in category A biothreat agents list under tier 1 biosecurity regulations always attract public attention about any possibility of a new form of this agent. Last time, a new type of botulinum neurotoxin (type G) was discovered was over 40 years ago, and that was not even known to cause human botulism epidemiologically. Therefore, when a novel botulinum neurotoxin was isolated from an infant botulism case in California, it became a major concern for the public health and biothreat agencies. There has been controversy among the scientists about its nomenclature. The scientific debate has been robust, and although the novel neurotoxin is now confirmed to be a hybrid of types A and F botulinum neurotoxins, the issue of calling it a new serotype (H) remains unsettled.
Keywords: antitoxins; biothreats; botulinum neurotoxins; BoNT; nomenclature; botulinum serotype; Clostridium botulinum; botulism; biosecurity.
The Botulinum Journal, 2015 Vol.3 No.1, pp.79 - 87
Received: 08 May 2021
Accepted: 12 May 2021
Published online: 29 Jun 2016 *