Title: An interactomic approach for identification of putative drug targets in Listeria monocytogenes
Authors: Nikita Chordia; Nilesh Kumar Sharma; Anil Kumar
Addresses: School of Biotechnology, Devi Ahilya University, Khandwa Road, Indore 452001, Madhya Pradesh, India ' School of Biotechnology, Devi Ahilya University, Khandwa Road, Indore 452001, Madhya Pradesh, India ' School of Biotechnology, Devi Ahilya University, Khandwa Road, Indore 452001, Madhya Pradesh, India
Abstract: A wide variety of human population is infected with Listeria monocytogenes, which causes listeriosis, a deadly disease with mortality rate of about 30%. The major hindrance to cure listeriosis is the unavailability of specific or selectable drug targets. At present, antibiotics used to cure the disease are not specific and insufficient to manage the disease efficiently. Therefore, in order to search specific drugs, here, we used interactome analysis to search specific drug targets which may provide novel templates for drug designing having better efficacy without any potential adverse effects. The complete genome of L. monocytogenes having 2846 proteins has been analysed. We found 11 proteins as putative drug targets. The sequence and interactome analyses revealed that 11 proteins are non-homologous to human, but essential for pathogen and hence may be considered as potential therapeutic targets.
Keywords: Listeria monocytogenes; listeriosis; drug targets; interactome analysis; proteome; metabolic pathways; non-homologus; cytoplasmic; cellular localisation; potential therapeutic targets; bioinformatics; drug design; proteins; protein sequences.
DOI: 10.1504/IJBRA.2015.070138
International Journal of Bioinformatics Research and Applications, 2015 Vol.11 No.4, pp.315 - 325
Accepted: 14 Jan 2015
Published online: 27 Jun 2015 *