Title: Putative drug targets in Rhizopus oryzae: in-silico insight.

Authors: Chakresh Kumar Jain; Ankita Dasgupta; Naina Taneja; Sonal Chaubey; Reema Gabrani; Sanjeev K. Sharma; Sanjay Gupta

Addresses: Department of Biotechnology, Jaypee Institute of Information Technology, A-10 Sector- 62, Noida, Uttar Pradesh 201307, India ' Department of Biotechnology, Jaypee Institute of Information Technology, A-10 Sector- 62, Noida, Uttar Pradesh 201307, India ' Department of Biotechnology, Jaypee Institute of Information Technology, A-10 Sector- 62, Noida, Uttar Pradesh 201307, India ' Department of Biotechnology, Jaypee Institute of Information Technology, A-10 Sector- 62, Noida, Uttar Pradesh 201307, India ' Department of Biotechnology, Jaypee Institute of Information Technology, A-10 Sector- 62, Noida, Uttar Pradesh 201307, India ' Department of Biotechnology, Jaypee Institute of Information Technology, A-10 Sector- 62, Noida, Uttar Pradesh 201307, India ' Department of Biotechnology, Jaypee Institute of Information Technology, A-10 Sector- 62, Noida, Uttar Pradesh 201307, India

Abstract: Opportunistic fungal infections, such as zygomycosis, often associated with excessive morbidity and mortality, are increasingly becoming a source of concern worldwide. In the reported investigation, genome analysis of a major opportunistic fungus Rhizopus oryzae was undertaken to identify gene or protein sequences that may serve as targets for therapeutic interventions. Using database of essential genes six proteins were identified. These proteins are implicated in metabolic/cellular pathways, which are more likely to be crucial for target organism's viability. Their utility as potential drug targets is discussed.

Keywords: zygomycosis; Rhizopus oryzae; riboflavin synthesis pathway; DEG; drug targets; opportunistic fungal infections; genome analysis; bioinformatics; protein sequences; gene sequences; therapeutic intervention.

DOI: 10.1504/IJBRA.2013.056621

International Journal of Bioinformatics Research and Applications, 2013 Vol.9 No.6, pp.595 - 603

Received: 10 Sep 2011
Accepted: 31 Oct 2011

Published online: 10 Aug 2013 *

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