Title: Meropenem: a potent drug against superbug as unveiled through bioinformatics approaches

Authors: Medhavi Mallick; Devang Odedra; Ambarish Sharan Vidyarthi; Shankaracharya

Addresses: Department of Biotechnology, Birla Institute of Technology, Mesra, Ranchi, 835215, India ' Department of Biotechnology, Birla Institute of Technology, Mesra, Ranchi, 835215, India ' Department of Biotechnology, Birla Institute of Technology, Mesra, Ranchi, 835215, India ' Department of Biotechnology, Birla Institute of Technology, Mesra, Ranchi, 835215, India

Abstract: Global spread of multi-drug resistant bacteria like Klebsiella pneumoniae and Escherichia coli have raised the alarm for researchers and doctors throughout the world. This new mechanism of resistance and the ability of ndm-1 gene to be transferred between the species may end the era of antibiotics treatment. Carbapenems are reliable drugs against many multi-resistant gram-negative pathogens. A 3-D homology model of NDM-1 was built and analysed for elucidation of functional site and binding interactions. This study revealed that meropenem has good interaction with the active sites of the receptor that could retard the spread of antibiotic resistant bacteria.

Keywords: superbugs; NDM-1 gene; New Delhi MBL; metallo-beta-lactamase; integron; meropenem; bioinformatics; carbapenems; homology modelling; functional sites; binding interactions; antibiotic resistant bacteria; drug resistant bacteria.

DOI: 10.1504/IJBRA.2013.052444

International Journal of Bioinformatics Research and Applications, 2013 Vol.9 No.2, pp.109 - 120

Received: 08 Oct 2010
Accepted: 06 Dec 2010

Published online: 05 Mar 2013 *

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