Title: Identifying cancer highly-expressed membrane receptors for targeted drug delivery

Authors: Wei-Chih Huang; Feng-Mao Lin; Tzu-Hao Chang; Kuang-Wen Liao; Hsien-Da Huang

Addresses: Institute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsin-Chu 300, Taiwan ' Institute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsin-Chu 300, Taiwan ' Institute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsin-Chu 300, Taiwan ' Department of Biological Science and Technology, National Chiao Tung University, Hsin-Chu 300, Taiwan; Institute of Molecular Medicine and Bioengineering, National Chiao-Tung University, Hsin-Chu 300, Taiwan ' Department of Biological Science and Technology, National Chiao Tung University, Hsin-Chu 300, Taiwan; Institute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsin-Chu 300, Taiwan

Abstract: Currently, the accompanying side effects of anti-cancer drugs owing to incorrect delivery to normal tissues should be reduced. We present a database (MRTDD) with identified cancer highly-expressed membrane receptors (CHMRs) which can be used in targeted drug delivery. To evaluate the probability of occurrence of incorrect delivery, we calculate tissue index for each CHMR and expect to identify good candidates. The information provided includes: (1) genomic annotations; (2) gene expression profiles of membrane receptors in cancer tissue vs. corresponding normal tissue, normal tissues of body and cancer cell-lines; (3) available antibody services of manufacturers. MRTDD is available at http://mrtdd.mbc.nctu.edu.tw/.

Keywords: targeted drug delivery; membrane receptors; microarray analysis; bioinformatics; anti-cancer drugs; genomic annotations; gene expression profiles; cancer tissue; cancer cells.

DOI: 10.1504/IJBRA.2012.048965

International Journal of Bioinformatics Research and Applications, 2012 Vol.8 No.3/4, pp.192 - 209

Published online: 05 Dec 2014 *

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