Title: Microarray data classification by multi-information based gene scoring integrated with Gene Ontology

Authors: Vincent S. Tseng, Hsieh-Hui Yu

Addresses: Department Computer Science and Information Engineering, National Cheng Kung University, Tainan, Taiwan. ' Department Computer Science and Information Engineering, National Cheng Kung University, Tainan, Taiwan

Abstract: Selecting informative genes is one of the most important issues for deciphering biological information hidden in gene expression data. However, due to the characteristics of microarray data with small samples and large number of genes, general feature selection methods that are not biologically relevant become questionable. In this paper, we propose a novel classification method for microarray data by integrating the multi-information based gene scoring method with biological information. Through experimental evaluation, our proposed method is shown to deliver good accuracy in classification and provide biologists with deeper insights into the relations between genes and gene function categories.

Keywords: microarray data classification; gene expression analysis; gene scoring; gene ontology; bioinformatics; microarrays.

DOI: 10.1504/IJDMB.2011.041556

International Journal of Data Mining and Bioinformatics, 2011 Vol.5 No.4, pp.402 - 416

Received: 30 Dec 2008
Accepted: 30 May 2009

Published online: 26 Jul 2011 *

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