Title: Prediction of disease causing gene in Xq22.1 region of human X-chromosome

Authors: Vidya Niranjan, Riaz Ahmed, R. Seenivasagam, G. Sivakumar

Addresses: Department of Bioinformatics, Outsource Bioinformatics, Development Center, Grand Residency, DG 4, Kanakapura Rd., Bangalore 560 078, India. ' Department of Biotechnology and Bioinformatics, Kuvempu University, Shankaraghatta, Karnataka 577 451, India. ' Department of Pharmacoinformatics, Outsource Bioinformatics, Development Center, Grand Residency, DG 4, Kanakapura Rd., Bangalore 560 078, India. ' Department of Pharmacoinformatics, School of Chemical and Biotechnology, Sastra University, Thanjavur 613 402, Tamil Nadu, India

Abstract: A comprehensive analysis of the X-chromosome led to the discovery of an important region found to be Xq22.1. Xq22.1 was analysed in detail to locate a credible gene carrying segment on it, which may be implicated in various disorders related to the X-chromosome. Finding genes in a genomic sequence is a fiddly problem. Hence, we developed a new in-silico approach to identify the novel gene, based on homology methods (extrinsic methods) and gene prediction methods (intrinsic methods).

Keywords: gene informatics; homology modelling; RT-PCR; in-silico analysis; protein validation; bioinformatics; X-chromosome; gene prediction.

DOI: 10.1504/IJBRA.2011.040092

International Journal of Bioinformatics Research and Applications, 2011 Vol.7 No.2, pp.130 - 145

Published online: 13 May 2011 *

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