Authors: Vidya Niranjan, Riaz Ahmed, R. Seenivasagam, G. Sivakumar
Addresses: Department of Bioinformatics, Outsource Bioinformatics, Development Center, Grand Residency, DG 4, Kanakapura Rd., Bangalore 560 078, India. ' Department of Biotechnology and Bioinformatics, Kuvempu University, Shankaraghatta, Karnataka 577 451, India. ' Department of Pharmacoinformatics, Outsource Bioinformatics, Development Center, Grand Residency, DG 4, Kanakapura Rd., Bangalore 560 078, India. ' Department of Pharmacoinformatics, School of Chemical and Biotechnology, Sastra University, Thanjavur 613 402, Tamil Nadu, India
Abstract: A comprehensive analysis of the X-chromosome led to the discovery of an important region found to be Xq22.1. Xq22.1 was analysed in detail to locate a credible gene carrying segment on it, which may be implicated in various disorders related to the X-chromosome. Finding genes in a genomic sequence is a fiddly problem. Hence, we developed a new in-silico approach to identify the novel gene, based on homology methods (extrinsic methods) and gene prediction methods (intrinsic methods).
Keywords: gene informatics; homology modelling; RT-PCR; in-silico analysis; protein validation; bioinformatics; X-chromosome; gene prediction.
International Journal of Bioinformatics Research and Applications, 2011 Vol.7 No.2, pp.130 - 145
Published online: 13 May 2011 *Full-text access for editors Access for subscribers Purchase this article Comment on this article