Title: Ingenuity in pattern recognition: a novel bioinformatics approach towards lung cancer identification

Authors: Jayant Mishra, Amit Kumar, Amita Sinha, Silpa Das, Akash Srivastava

Addresses: BioAxis DNA Research Centre Pvt. Ltd., Hyderabad 500017, Andhra Pradesh, India. ' BioAxis DNA Research Centre Pvt. Ltd., Hyderabad 500017, Andhra Pradesh, India. ' BioAxis DNA Research Centre Pvt. Ltd., Hyderabad 500017, Andhra Pradesh, India. ' BioAxis DNA Research Centre Pvt. Ltd., Hyderabad 500017, Andhra Pradesh, India. ' SRM University, Chennai (India)

Abstract: Lung cancer is the significant contributor of increased cancer deaths. Earlier research indicates that the environmental factors have a major role in causing lung cancer. It is evident that the pathway of lung cancer includes both RAS-mediated and non-RAS-mediated mechanisms. Clinical findings point to a wide variety of other cancers contributing to lung cancer incidence. Such a scenario makes identification of lung cancer difficult and thus identifying its mechanisms can contribute to the society. Our study involves the RAS subfamily that includes a set of proteins, which cause an over expression of cancer-causing genes like M-ras and initiate tumour formation in lungs.

Keywords: lung cancer genes; gene expression; M-ras; smokers; RAS subfamily; lung cancer database; lung cancer diagnosis; lung cancer identification; bioinformatics; pattern recognition; proteins; tumour formation; smoking.

DOI: 10.1504/IJBRA.2010.038735

International Journal of Bioinformatics Research and Applications, 2010 Vol.6 No.6, pp.531 - 541

Published online: 24 Feb 2011 *

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