Title: Low dose response of human lymphocytes in vitro and its dependence on the antioxidant status of donor persons

Authors: G.J. Koteles, I. Bojtor, G. Bognar, M. Otos

Addresses: ''Frederic Joliot-Curi'', National Research Institute for Radiobiology and Radiohygiene, PO Box 101, H 1775 Budapest, Hungary. ''Frederic Joliot-Curi'', National Research Institute for Radiobiology and Radiohygiene, PO Box 101, H 1775 Budapest, Hungary. ''Frederic Joliot-Curi'', National Research Institute for Radiobiology and Radiohygiene, PO Box 101, H 1775 Budapest, Hungary. ''Frederic Joliot-Curi'', National Research Institute for Radiobiology and Radiohygiene, PO Box 101, H 1775 Budapest, Hungary

Abstract: The individual responses of persons were studied in vitro by lymphocyte micronucleus assay following X-irradiations of 0.7 and 0.25 Gy. Linear correlations of a different coefficient, R, were found with the normal total antioxidant level (TAS value) of the donors| sera: the higher the antioxidant status the less the radiation-induced micronucleus increment. The cytogenetic effect of low doses could be significantly protected above approximately 1.6 mmol l^-1 of TAS. Accordingly, the resistance in population, as it were, could be increased by long-lasting consumption of vitamins C and E when the initial TAS values must have been elevated.

Keywords: low dose; lymphocyte micronuclei; antioxidant level; antioxidant protection.

DOI: 10.1504/IJLR.2003.003481

International Journal of Low Radiation, 2003 Vol.1 No.1, pp.147 - 154

Published online: 11 Sep 2003 *

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