Title: New algebraic constructions for pooling design in DNA library screening

Authors: Zengti Li, Suogang Gao, Hongjie Du, Yan Shi, Weili Wu

Addresses: Mathematics and Information College, Langfang Normal College, Langfang 065000, China. ' Mathematics and Information College, Hebei Normal University, Shijiazhuang 050016, China. ' Department of Computer Science, University of Texas at Dallas, Richardson, Texas 75080, USA. ' Department of Computer Science, University of Texas at Dallas, Richardson, Texas 75080, USA. ' Department of Computer Science, University of Texas at Dallas, Richardson, Texas 75080, USA

Abstract: Pooling design is an important mathematical tool in DNA library screening. It has been showed that using pooling design, the number of tests in DNA library screening can be greatly reduced. In this paper, we present some new algebraic constructions for pooling design.

Keywords: pooling design; se-disjunct matrix; finite fields; affine unitary space; (d, r)-flat; DNA library screening; bioinformatics.

DOI: 10.1504/IJBRA.2010.034078

International Journal of Bioinformatics Research and Applications, 2010 Vol.6 No.3, pp.308 - 322

Received: 23 Aug 2009
Accepted: 23 Oct 2009

Published online: 07 Jul 2010 *

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